36 articles - From Saturday Apr 23 2022 to Friday Apr 29 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
2022 EULAR points to consider for remote care in rheumatic and musculoskeletal diseases. The PtC have identified areas where telehealth could improve quality of care and increase healthcare access. Knowing about drivers and barriers of telehealth is a prerequisite to successfully establish remote care approaches in rheumatologic clinical practice. |
Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function. Our study identifies auxilin as the first genetic susceptibility factor in NLE modulating cardiac function, opening new avenues for the development of screening and therapeutic strategies in CHB. |
Biological impact of iberdomide in patients with active systemic lupus erythematosus. Iberdomide significantly reduced activity of type I IFN and B cell pathways, and increased IL-2 and Tregs, suggesting a selective rebalancing of immune abnormalities in SLE. Clinical efficacy corresponded to reduction of the type I IFN gene signature. |
Concise report: a minimal-invasive method to retrieve and identify entheseal tissue from psoriatic arthritis patients. Entheseal biopsy of the lateral epicondyle is feasible in patients with PsA allowing reliable retrieval of entheseal tissue and its identification by SHG microscopy. |
Isolation of HLA-DR-naturally presented peptides identifies T-cell epitopes for rheumatoid arthritis. We significantly expanded the peptide repertoire presented by HLA-DR molecules in a physiologically relevant context, identifying six new epitopes recognised by CD4 +T cells from patients with RA. This information is important for a better understanding of the disease immunopathology, as well as for designing tolerising antigen-specific immunotherapies. |
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset. Sequence variants pointing to causal genes in the JAK/STAT pathway have largest effect on seropositive RA, while associations with seronegative RA remain scarce. |
| Arthritis Care Res (Hoboken) |
Associations of Socioeconomic Status with Disease Progression in African Americans with Early Rheumatoid Arthritis. Low educational attainment and non-professional occupation status were associated with increased worsening of PROs. However, there were no corresponding increases in radiographically assessed erosion or JSN score progression. |
Cost-effectiveness of group-based outpatient physical therapy after total knee replacement: results from the economic evaluation alongside the ARENA multicentre randomised controlled trial. The addition of group-based outpatient physical therapy classes to usual care improves quality-of-life and is a cost-effective treatment option following TKR for a society willing-to-pay £20,000 per QALY gained. |
Race, ethnicity, and disparities in risk of end-organ lupus manifestations following SLE diagnosis in a multiethnic cohort. We found heightened risks of developing renal, hematologic, and multiorgan disease following SLE diagnosis among Hispanic and Asian patients with SLE, as well as a high burden of multiorgan disease among CLUES participants. |
| Arthritis Res Ther |
HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status. HLA-DRB1 haplotypes associated with susceptibility to RA also predispose to increased risk of CV mortality in IP, independent of known CV risk factors. Associations were independent of anti-CCP status, which suggests in the future, genetic factors will add to the prediction of risk of cardiovascular mortality beyond serological markers. |
Systemic sclerosis and pregnancy outcomes: a retrospective study from a single center. We found an increased risk of APO in our SSc cohort in comparison with HC (with higher rates of miscarriages, preeclampsia, SGA newborns, and preterm deliveries) and SLE patients (presenting a higher rate of preterm deliveries). High-risk multidisciplinary management of SSc pregnant women is highly recommended. |
| Arthritis Rheumatol |
American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 4. These guidance statements are intended to provide direction to rheumatology health care providers on how to best use COVID-19 vaccines and to facilitate implementation of vaccination strategies for RMD patients. |
Effects of anti-TNF-therapy on inflammatory, structural and osteoblastic activity lesions in radiographic axial spondyloarthritis - a prospective proof-of-concept study using PET/MRI of SIJ and spine. Anti-TNF treatment led to significant decrease of osteoblastic activity within 3-6 months, especially but not solely at sites with inflammation. Larger datasets are needed for confirmation of the anti-osteoblastic effects of TNF-inhibitors for prevention of radiographic progression in axSpA. |
Over one-third of Th/To antibody positive scleroderma patients develop pulmonary hypertension in long-term follow-up. This is the largest cohort of anti-Th/To positive SSc patients with long-term follow-up data. Striking is the very high rate (38%) and associated independent risk of anti-Th/To patients developing PH in follow-up, particularly Group 1 PAH. Patients presenting with limited skin involvement should be tested for Th/To antibody. If present, careful monitoring for PH is warranted. |
Performance of the 2017 EULAR/ACR classification criteria in anti-MDA5 associated idiopathic inflammatory myopathy. Almost 30% of patients with clinical anti-MDA5 associated IIM could not be classified by the EULAR/ACR criteria. Modification of the existing criteria incorporating anti-MDA5 antibody or development of a new specific set of criteria for "anti-MDA5 syndrome" are suggested. |
| Rheumatology (Oxford) |
Baseline Factors Associated with Self-reported Disease Flares Following COVID-19 Vaccination among Adults with Systemic Rheumatic Disease: Results from the COVID-19 Global Rheumatology Alliance Vaccine Survey. SRD flares requiring changes in treatment following COVID-19 vaccination were uncommon in this large international study. Several potential risk factors, as well as differences by disease type, warrant further examination in prospective cohorts. |
Clinical characteristics and risk factors associated with lymphoma in patients with systemic lupus erythematosus: a nationwide cohort study. In this large multicentre Spanish cohort, we identified characteristics of SLE that are associated with a higher risk of lymphoma. Antimalarials were significantly negatively associated with risk of lymphoma in SLE patients. Nevertheless, further prospective studies are needed to clarify these findings. |
Evaluation of Left Cardiac Chamber Function with Cardiac Magnetic Resonance and Association with Outcome in Patients with Systemic Sclerosis. In patients with SSc, LARS was independently associated with the presence of NYHA class II-IV heart failure symptoms. Although both LARS and LV GLS were associated with all-cause mortality, only LARS provided incremental value over al evaluated variables known to be prognostically important in patients with SSc. |
Major determinants of prolonged remission in systemic lupus erythematosus: retrospective study over a 41-year period. Patients not achieving any kind of sustained remission have a higher risk of early mortality. White ethnicity, older age at diagnosis, absence of renal involvement and of APS were significantly associated with CR. Predictors for sustained CR do not change whether a 3-year or 5-year period is applied. |
Musculoskeletal ultrasound may narrow the gap between patients and physicians in the assessment of rheumatoid arthritis disease activity. Patient-physician discordance is associated with the lack of US remission in patients with RA and may represent a further indication for MSUS. |
Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD8+ T cells in giant cell arteritis. In GCA, circulating effector memory CD8+ T cells demonstrate a proliferation-prone phenotype. The presence of CD8+ T cells in inflamed arteries seems to reflect recruitment of circulating cells rather than local expansion. CD8+ T cells in inflamed tissues produce IFN- |
Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogen. There is a strong site-specific association between pharyngeal culture samples and an increased risk of PsA and psoriasis, regardless of the pathogen. This may indicate that the site of infection, rather than the pathogen, is associated with increased risk. |
The impact of psoriasis on the clinical characteristics, disease burden and treatment patterns of peripheral spondyloarthritis. The presence of psoriasis has an impact on clinical characteristics of pSpA. pSpA patients without psoriasis were less frequently treated with bDMARDs despite similar disease burden as compared with patients with psoriasis. |
Trends in risk factor control in patients with gout: data from the National Health and Nutrition Examination Survey, 2007-2018. Based on NHANES data, a significant trend towards decreased blood pressure control was observed in patients with gout, while glycemic and lipid control leveled off. These findings emphasize that more endeavors are needed to improve management of cardiovascular risk factors in patients with gout. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Ann Rheum Dis |
Systematic literature review of observational cohorts and clinical trials into the success rate of glucocorticoid discontinuation after their use as bridging therapy in patients with rheumatoid arthritis. The success rate of GC discontinuation after bridging as part of initial treatment of RA has been described in a limited number of studies. Reports on observational cohorts did not answer the research question. In clinical trials, protocolised discontinuation was mostly successful, although 22% of the patients who started GC bridging therapy still or again used GC at 12 months, and 10% at 24 months. |
Letters to the editors and authors’ replies
| Arthritis Res Ther |
The role of interleukin (IL)-23 in regulating pain in arthritis. Encouragingly, the anti-IL-23p19 mAb, guselkumab, reduces pain in psoriatic arthritis patients. Recent evidence has suggested a new biology for IL-23, whereby IL-23 is required in models of innate immune-mediated arthritis and its associated pain with its action being linked to a GM-CSF-dependent pathway (the so-called GM-CSF |
| Arthritis Rheumatol |
all remaining publications eg case reports, images of the month, etc…
| Ann Rheum Dis |
| Arthritis Rheumatol |
| Rheumatology (Oxford) |